Flatiron Health operates a global oncology data engine that captures structured and unstructured patient data directly from clinical sources, including electronic health records (EHRs), and transforms it into research-grade real-world evidence (RWE). The platform leverages large language models (LLMs) for tasks such as thematic analysis of clinical trial discussions and machine learning (ML) models for clinical prediction (e.g., predicting rapid disease progression). Their newly launched Flatiron Telescope is an AI platform designed to surface oncology insights in minutes, abstracting complex multi-source data pipelines into researcher- and clinician-friendly interfaces. The system integrates biomarker testing data, treatment history, and clinical outcomes to support both retrospective studies and prospective decision support.